Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.
Identifieur interne : 002067 ( Main/Exploration ); précédent : 002066; suivant : 002068Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.
Auteurs : J J Treanor ; E L Tierney ; S L Zebedee ; R A Lamb ; B R MurphySource :
- Journal of Virology [ 0022-538X ] ; 1990.
Abstract
The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S.L. Zebedee and R.A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.
Url:
PubMed: 2304147
PubMed Central: 249260
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000393
- to stream Pmc, to step Curation: 000393
- to stream Pmc, to step Checkpoint: 000D19
- to stream Ncbi, to step Merge: 000819
- to stream Ncbi, to step Curation: 000819
- to stream Ncbi, to step Checkpoint: 000819
- to stream Main, to step Merge: 002168
- to stream Main, to step Curation: 002067
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.</title><author><name sortKey="Treanor, J J" sort="Treanor, J J" uniqKey="Treanor J" first="J J" last="Treanor">J J Treanor</name></author><author><name sortKey="Tierney, E L" sort="Tierney, E L" uniqKey="Tierney E" first="E L" last="Tierney">E L Tierney</name></author><author><name sortKey="Zebedee, S L" sort="Zebedee, S L" uniqKey="Zebedee S" first="S L" last="Zebedee">S L Zebedee</name></author><author><name sortKey="Lamb, R A" sort="Lamb, R A" uniqKey="Lamb R" first="R A" last="Lamb">R A Lamb</name></author><author><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">2304147</idno><idno type="pmc">249260</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC249260</idno><idno type="RBID">PMC:249260</idno><date when="1990">1990</date><idno type="wicri:Area/Pmc/Corpus">000393</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000393</idno><idno type="wicri:Area/Pmc/Curation">000393</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000393</idno><idno type="wicri:Area/Pmc/Checkpoint">000D19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D19</idno><idno type="wicri:Area/Ncbi/Merge">000819</idno><idno type="wicri:Area/Ncbi/Curation">000819</idno><idno type="wicri:Area/Ncbi/Checkpoint">000819</idno><idno type="wicri:doubleKey">0022-538X:1990:Treanor J:passively:transferred:monoclonal</idno><idno type="wicri:Area/Main/Merge">002168</idno><idno type="wicri:Area/Main/Curation">002067</idno><idno type="wicri:Area/Main/Exploration">002067</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.</title><author><name sortKey="Treanor, J J" sort="Treanor, J J" uniqKey="Treanor J" first="J J" last="Treanor">J J Treanor</name></author><author><name sortKey="Tierney, E L" sort="Tierney, E L" uniqKey="Tierney E" first="E L" last="Tierney">E L Tierney</name></author><author><name sortKey="Zebedee, S L" sort="Zebedee, S L" uniqKey="Zebedee S" first="S L" last="Zebedee">S L Zebedee</name></author><author><name sortKey="Lamb, R A" sort="Lamb, R A" uniqKey="Lamb R" first="R A" last="Lamb">R A Lamb</name></author><author><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="1990">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S.L. Zebedee and R.A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Lamb, R A" sort="Lamb, R A" uniqKey="Lamb R" first="R A" last="Lamb">R A Lamb</name><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name><name sortKey="Tierney, E L" sort="Tierney, E L" uniqKey="Tierney E" first="E L" last="Tierney">E L Tierney</name><name sortKey="Treanor, J J" sort="Treanor, J J" uniqKey="Treanor J" first="J J" last="Treanor">J J Treanor</name><name sortKey="Zebedee, S L" sort="Zebedee, S L" uniqKey="Zebedee S" first="S L" last="Zebedee">S L Zebedee</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002067 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002067 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:249260
|texte= Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:2304147" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |